American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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Prepare for the American Board of Surgery Qualifying Exam with detailed quizzes. Study with flashcards and multiple-choice questions to master the ABS QE topics. Get all the hints and explanations you need to succeed on your first attempt!

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Which side effect is commonly associated with FK506 (Tacrolimus)?

Nephrotoxic effects
Hyperlipidemia
Weight gain
Cardiomyopathy

The correct answer is: Nephrotoxic effects

Tacrolimus, also known as FK506, is an immunosuppressant commonly used in organ transplantation to prevent rejection. One of the significant side effects associated with its use is nephrotoxicity. This toxic effect on the kidneys can present as a decrease in renal function, which is often monitored through serum creatinine levels. Tacrolimus exerts its nephrotoxic effects primarily by causing vasoconstriction of the afferent arterioles in the renal glomeruli, leading to reduced renal blood flow and consequent damage. This side effect is particularly relevant in the context of long-term use of tacrolimus, as the cumulative effect can lead to chronic kidney disease, requiring careful monitoring of renal function and sometimes dosage adjustments to mitigate this risk. Recognizing the potential for nephrotoxicity is critical for clinicians managing patients on tacrolimus to ensure the best possible patient outcomes while bridging the balance of immunosuppression and maintaining kidney health.