American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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Which side effect is associated with Cyclosporin regarding the nervous system?

Drowsiness
Seizures
Neuropathy
Headaches

The correct answer is: Seizures

Cyclosporine is an immunosuppressive medication commonly used in organ transplantation and in autoimmune disorders. One of the potential neurological side effects associated with cyclosporine is seizures. Although seizures can arise from various causes, in the case of cyclosporine, they may be attributed to the drug’s impact on blood pressure and the potential for renal impairment, which can subsequently lead to alterations in cerebral perfusion. Additionally, cyclosporine can affect electrolyte imbalances, such as hyperkalemia or hypomagnesemia, both of which can contribute to seizure activity. While drowsiness, neuropathy, and headaches are not typically highlighted as prevalent side effects associated with cyclosporine, the correlation between cyclosporine use and seizures is well documented in clinical literature, making it the most supported answer in the context of nervous system side effects.