American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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Prepare for the American Board of Surgery Qualifying Exam with detailed quizzes. Study with flashcards and multiple-choice questions to master the ABS QE topics. Get all the hints and explanations you need to succeed on your first attempt!

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What is the role of V2 receptors in the action of vasopressin?

Arterial constriction
Water reabsorption at collecting ducts
Release of coagulation factors
Vasodilation

The correct answer is: Water reabsorption at collecting ducts

V2 receptors are integral to the mechanism of action of vasopressin, also known as antidiuretic hormone (ADH). They are primarily located in the renal collecting ducts. When vasopressin binds to V2 receptors, it triggers a signaling cascade that leads to the insertion of aquaporin-2 channels into the apical membrane of the renal tubular cells. This process enhances the reabsorption of water back into the bloodstream, which concentrates the urine and reduces urine output. Therefore, the role of V2 receptors is fundamentally linked to promoting water reabsorption, helping to regulate body fluid balance and maintain blood pressure. The other options do not accurately reflect the function of V2 receptors associated with vasopressin. Arterial constriction is primarily associated with V1 receptors. The release of coagulation factors is unrelated to vasopressin receptors, focusing instead on different hormonal responses and pathways in hemostasis. Vasodilation is also not a function of the V2 receptor; rather, it may be influenced by other pathways and receptors in the body.