American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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What is the most common side effect associated with Mycophenolate mofetil?

Rash
GI intolerance
Neuropathy
Dry mouth

The correct answer is: GI intolerance

Mycophenolate mofetil is an immunosuppressant commonly used in organ transplantation and autoimmune conditions. The most prevalent side effect associated with this medication is gastrointestinal (GI) intolerance, which often manifests as nausea, diarrhea, vomiting, and abdominal pain. This can significantly affect a patient's quality of life and adherence to medication. The mechanism behind this GI intolerance is related to the drug's action on rapidly dividing cells in the gastrointestinal tract, leading to disturbances in normal gut function. Patients taking Mycophenolate mofetil frequently report these side effects, making monitoring and management of GI symptoms crucial during treatment. While other side effects, such as rash, neuropathy, and dry mouth, can occur, they are considerably less common compared to the gastrointestinal issues associated with Mycophenolate mofetil. Understanding this side effect is important for clinicians in predicting and managing patient responses to the medication.