American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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What additional condition is specifically associated with Gardner's Syndrome?

  1. Pheochromocytomas

  2. Familial adenomatous polyposis (FAP)

  3. Neurofibromatosis type 1

  4. Melanoma

The correct answer is: Familial adenomatous polyposis (FAP)

Gardner's Syndrome is specifically associated with familial adenomatous polyposis (FAP) because it is actually considered a variant of FAP. This genetic disorder is characterized by the development of numerous colorectal polyps in adolescence, with a nearly 100% risk of developing colorectal cancer if left untreated. In addition to these polyps, individuals with Gardner's Syndrome often present with extracolonic manifestations, which may include osteomas, dental abnormalities, and soft tissue tumors. The direct association with FAP emphasizes the importance of genetic counseling and management strategies to monitor and mitigate the risk of colorectal cancer. In contrast, while the other conditions listed may have overlapping features or genetic bases, they do not have the same direct connection or are not considered manifestations of Gardner's Syndrome itself.

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